In biochemistry and pharmacology, the Hill equation refers to two closely related equations that reflect the binding of ligands to macromolecules, as a function of the ligand concentration. A ligand is "a substance that … See more

The Hill coefficient is a measure of ultrasensitivity (i.e. how steep is the response curve).
The Hill coefficient, $${\displaystyle n}$$ or See more

The Hill equation is used extensively in pharmacology to quantify the functional parameters of a drug and are also used in other areas of … See more

The Hill equation is commonly expressed in the following ways.
,
where: See more

A distinction should be made between quantification of drugs binding to receptors and drugs producing responses. There may not necessarily … See more

The most common form of the Hill equation is its irreversible form. However, when building computational models a reversible form is … See more

Because of its assumption that ligand molecules bind to a receptor simultaneously, the Hill equation has been criticized as a physically unrealistic model. Moreover, the Hill coefficient should not be considered a reliable approximation of the number of … See more